Readme: Descriptive data for USN Research Data Archive Dataset generated by Hilde R. Pedersen and Rigmor C. Baraas ------------------- GENERAL INFORMATION ------------------- TITLE FOR THE DATASET The cone photoreceptor mosaic in aniridia: within-family phenotype-genotype discordance OCT_RetinalLayers_Aniridia: Measured retinal layer thicknesses for seven persons with congenital aniridia CONTACT INFORMATION Professor Rigmor C. Baraas University of South-Eastern Norway Hasbergsvei 36 3616 Kongsberg Norway rigmor.baraas@usn.no DATA COLLECTION 2015–2018 in Norway LANGUAGE English ---------------- FILE INFORMATION ---------------- The files are comma-separated text files and can be imported into R statistical software, Excel or other spreadsheet programs. For each participant, layers and thicknesses are shown with respect to lateral eccentricity from the foveal center, in 0.1 degree increments. All thickness measurements are in microns (µm). Retinal eccentricities from the foveal center (xpos) are in degrees. Negative numbers represent the nasal meridian and positive numbers the temporal meridian. xpos_r are retinal eccentricities rounded to nearest 0.1 degree. ----------- METHODOLOGY ----------- SD-OCT images are acquired with the Heidelberg Spectralis OCT2 (Heidelberg Engineering GmbH, Heidelberg; Germany). Retinal layers are segmented at the anterior egde of the inner limiting membrane (ILM), the posterior boundary of the outer plexiform layer (OPL), center of the external limiting membrane (ELM), ellipsoid zone (EZ) and interdigitation zone (IZ), and the posterior boundary RPE-Bruch’s Membrane (RPE) band using semi-automatic custom software. Thickness of retinal layers are calculated and defined as: Retinal thickness (RT): ILM - RPE Outer nuclear layer thickness (ONLT): OPL - ELM Inner segments (IS): ELM - EZ Outer segments (OS): EZ - IZ The lateral scaling (microns_per_pixel) is corrected for retinal magnification based on individual ocular biometry, calculated with optical design software using the Liou & Brennan eye model (Liou HL, Brennan NA.,J Opt Soc Am A Opt Image Sci Vis. 1997;14:1684-1695). These data are for each participant’s dominant eye.